Heparin sodium CAS 9041-08-1

Heparin sodium ndi anticoagulant mankhwala, amene ndi mucopolysaccharide mankhwala.Ndi sodium mchere wa glucosamine sulphate yotengedwa mucosa matumbo nkhumba, ng'ombe ndi nkhosa.pakati.Sodium ya heparin imakhala ndi ntchito zoletsa kuphatikizika kwa mapulateleti ndi kuwononga, kuletsa kutembenuka kwa fibrinogen kukhala fibrin monomer, kuletsa mapangidwe a thromboplastin ndikukana kupanga thromboplastin, kuteteza kutembenuka kwa prothrombin kukhala thrombin ndi antithrombin.

Heparin sodium imatha kuchedwetsa kapena kuletsa kutsika kwa magazi mu vitro komanso mu vivo.Njira yake yochitira zinthu ndizovuta kwambiri ndipo imakhudza maulalo ambiri munjira ya coagulation.Ntchito zake ndi: ①Kuletsa mapangidwe ndi ntchito ya thromboplastin, potero kulepheretsa prothrombin kukhala thrombin;②Pokwera kwambiri, imatha kuletsa thrombin ndi zinthu zina za coagulation, kulepheretsa fibrinogen kukhala mapuloteni a fibrin;③ imatha kuteteza kuphatikizika ndi kuwonongeka kwa mapulateleti.Kuphatikiza apo, mphamvu ya anticoagulant ya sodium heparin ikadali yokhudzana ndi sulphate yoyipa kwambiri mu molekyulu yake.Zinthu zamchere zokhala ndi zopatsa mphamvu monga protamine kapena toluidine buluu zimatha kuletsa kuwononga kwake, kotero zimatha kuletsa anticoagulant yake.coagulation.Chifukwa heparin imatha kuyambitsa ndikutulutsa lipoprotein lipase m'thupi, hydrolyze triglyceride ndi low-density lipoprotein mu ma chylomicrons, motero imakhala ndi hypolipidemic effect.

Heparin sodium angagwiritsidwe ntchito pochiza pachimake thromboembolic matenda, disseminated intravascular coagulation (DIC).M'zaka zaposachedwa, heparin yapezeka kuti ili ndi zotsatira zochotsa lipids zamagazi.Jakisoni wolowera m'mitsempha kapena jekeseni wakuya wa muscular (kapena jekeseni wa subcutaneous), mayunitsi 5,000 mpaka 10,000 nthawi iliyonse.Heparin sodium ndi wochepa poizoni ndipo mowiriza chizolowezi magazi ndiye wofunika kwambiri chiopsezo heparin overdose.Zosagwira ntchito pakamwa, ziyenera kuperekedwa ndi jakisoni.Jekeseni wa intramuscular kapena subcutaneous jekeseni amakwiyitsa kwambiri, nthawi zina ziwengo zimatha kuchitika, ndipo kumwa mopitirira muyeso kumatha kuyambitsa kumangidwa kwa mtima;nthawi zina tsitsi limatayika komanso kutsekula m'mimba.Kuphatikiza apo, imatha kuyambitsa kusweka kwapawiri.Kugwiritsa ntchito nthawi yayitali nthawi zina kungayambitse thrombosis, zomwe zingakhale zotsatira za kuchepa kwa anticoagulase-III.Heparin sodium ndi contraindicated odwala ndi magazi chizolowezi, aakulu chiwindi ndi aimpso insufficiency, aakulu matenda oopsa, hemophilia, intracranial kukha mwazi, chironda chachikulu, amayi apakati ndi postpartum, zotupa visceral, zoopsa ndi opaleshoni.